A Review of Current Trends and Advances in Analytical Methods for Determination of ACE Inhibitors Combinations with Hydrochlorothiazide

Imad Osman Abu Reid; Sayda Mohamed Osman; Somia Mohammed Bakheet

doi:doi:10.11648/j.jddmc.20251102.11

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A Review of Current Trends and Advances in Analytical Methods for Determination of ACE Inhibitors Combinations with Hydrochlorothiazide

Imad Osman Abu Reid^*

, Sayda Mohamed Osman

, Somia Mohammed Bakheet

Published in Journal of Drug Design and Medicinal Chemistry (Volume 11, Issue 2)

Received: 31 January 2025 Accepted: 28 February 2025 Published: 24 May 2025

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Abstract

Background. Hypertension is a leading risk factor for cardiovascular diseases, contributing significantly to global morbidity and mortality. Combination therapy using an angiotensin-converting enzyme (ACE) inhibitor with a diuretic offers distinct advantages over monotherapy in managing hypertension. With the increasing use of fixed-dose combination therapies, there is a growing demand for analytical methods that can accurately, precisely, and cost-effectively assess these complex formulations. Objective. This review examines the various analytical methods used to analyze ACE inhibitor combinations with hydrochlorothiazide, focusing on studies published between 1990 and 2024. The methods are critically evaluated, compared, and assessed for their practical applicability. Results. A review of the literature revealed that different analytical techniques have been employed for the determination of ACE inhibitor–hydrochlorothiazide combinations. Recent trends indicate a preference for HPLC (48.7%), spectrophotometric methods (23.1%), thin-layer chromatography (TLC) (15.4%), capillary electrophoresis (7.7%), and Fourier transform infrared (FTIR) spectroscopy (5.1%). Conclusion and main ideas. HPLC remains the gold standard for the analysis of ACE inhibitor–hydrochlorothiazide combinations. However, alternative methods like spectrophotometry and TLC provide viable options for simpler and cost-effective analysis The selection of an appropriate analytical technique should align with analytical goals, regulatory compliance, and available resources. Future research may focus on advancing rapid and environmentally friendly analytical techniques.

Published in	Journal of Drug Design and Medicinal Chemistry (Volume 11, Issue 2)
DOI	10.11648/j.jddmc.20251102.11
Page(s)	13-30
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2025. Published by Science Publishing Group

Keywords

ACE Inhibitors, Hydrochlorothiazide, Combination, Determination

References

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Reid, I. O. A., Osman, S. M., Bakheet, S. M. (2025). A Review of Current Trends and Advances in Analytical Methods for Determination of ACE Inhibitors Combinations with Hydrochlorothiazide. Journal of Drug Design and Medicinal Chemistry, 11(2), 13-30. https://doi.org/10.11648/j.jddmc.20251102.11

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Reid, I. O. A.; Osman, S. M.; Bakheet, S. M. A Review of Current Trends and Advances in Analytical Methods for Determination of ACE Inhibitors Combinations with Hydrochlorothiazide. J. Drug Des. Med. Chem. 2025, 11(2), 13-30. doi: 10.11648/j.jddmc.20251102.11

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Reid IOA, Osman SM, Bakheet SM. A Review of Current Trends and Advances in Analytical Methods for Determination of ACE Inhibitors Combinations with Hydrochlorothiazide. J Drug Des Med Chem. 2025;11(2):13-30. doi: 10.11648/j.jddmc.20251102.11

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@article{10.11648/j.jddmc.20251102.11,
  author = {Imad Osman Abu Reid and Sayda Mohamed Osman and Somia Mohammed Bakheet},
  title = {A Review of Current Trends and Advances in Analytical Methods for Determination of ACE Inhibitors Combinations with Hydrochlorothiazide
},
  journal = {Journal of Drug Design and Medicinal Chemistry},
  volume = {11},
  number = {2},
  pages = {13-30},
  doi = {10.11648/j.jddmc.20251102.11},
  url = {https://doi.org/10.11648/j.jddmc.20251102.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jddmc.20251102.11},
  abstract = {Background. Hypertension is a leading risk factor for cardiovascular diseases, contributing significantly to global morbidity and mortality. Combination therapy using an angiotensin-converting enzyme (ACE) inhibitor with a diuretic offers distinct advantages over monotherapy in managing hypertension. With the increasing use of fixed-dose combination therapies, there is a growing demand for analytical methods that can accurately, precisely, and cost-effectively assess these complex formulations. Objective. This review examines the various analytical methods used to analyze ACE inhibitor combinations with hydrochlorothiazide, focusing on studies published between 1990 and 2024. The methods are critically evaluated, compared, and assessed for their practical applicability. Results. A review of the literature revealed that different analytical techniques have been employed for the determination of ACE inhibitor–hydrochlorothiazide combinations. Recent trends indicate a preference for HPLC (48.7%), spectrophotometric methods (23.1%), thin-layer chromatography (TLC) (15.4%), capillary electrophoresis (7.7%), and Fourier transform infrared (FTIR) spectroscopy (5.1%). Conclusion and main ideas. HPLC remains the gold standard for the analysis of ACE inhibitor–hydrochlorothiazide combinations. However, alternative methods like spectrophotometry and TLC provide viable options for simpler and cost-effective analysis The selection of an appropriate analytical technique should align with analytical goals, regulatory compliance, and available resources. Future research may focus on advancing rapid and environmentally friendly analytical techniques.
},
 year = {2025}
}

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TY - JOUR
T1 - A Review of Current Trends and Advances in Analytical Methods for Determination of ACE Inhibitors Combinations with Hydrochlorothiazide

AU - Imad Osman Abu Reid
AU - Sayda Mohamed Osman
AU - Somia Mohammed Bakheet
Y1 - 2025/05/24
PY - 2025
N1 - https://doi.org/10.11648/j.jddmc.20251102.11
DO - 10.11648/j.jddmc.20251102.11
T2 - Journal of Drug Design and Medicinal Chemistry
JF - Journal of Drug Design and Medicinal Chemistry
JO - Journal of Drug Design and Medicinal Chemistry
SP - 13
EP - 30
PB - Science Publishing Group
SN - 2472-3576
UR - https://doi.org/10.11648/j.jddmc.20251102.11
AB - Background. Hypertension is a leading risk factor for cardiovascular diseases, contributing significantly to global morbidity and mortality. Combination therapy using an angiotensin-converting enzyme (ACE) inhibitor with a diuretic offers distinct advantages over monotherapy in managing hypertension. With the increasing use of fixed-dose combination therapies, there is a growing demand for analytical methods that can accurately, precisely, and cost-effectively assess these complex formulations. Objective. This review examines the various analytical methods used to analyze ACE inhibitor combinations with hydrochlorothiazide, focusing on studies published between 1990 and 2024. The methods are critically evaluated, compared, and assessed for their practical applicability. Results. A review of the literature revealed that different analytical techniques have been employed for the determination of ACE inhibitor–hydrochlorothiazide combinations. Recent trends indicate a preference for HPLC (48.7%), spectrophotometric methods (23.1%), thin-layer chromatography (TLC) (15.4%), capillary electrophoresis (7.7%), and Fourier transform infrared (FTIR) spectroscopy (5.1%). Conclusion and main ideas. HPLC remains the gold standard for the analysis of ACE inhibitor–hydrochlorothiazide combinations. However, alternative methods like spectrophotometry and TLC provide viable options for simpler and cost-effective analysis The selection of an appropriate analytical technique should align with analytical goals, regulatory compliance, and available resources. Future research may focus on advancing rapid and environmentally friendly analytical techniques.

VL - 11
IS - 2
ER -

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Imad Osman Abu Reid

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International University of Africa, Khartoum, Sudan

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http://orcid.org/0000-0002-1381-1369
Sayda Mohamed Osman

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International University of Africa, Khartoum, Sudan

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http://orcid.org/0009-0002-3561-9922
Somia Mohammed Bakheet

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International University of Africa, Khartoum, Sudan

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http://orcid.org/0009-0009-9772-7903

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Reid, I. O. A., Osman, S. M., Bakheet, S. M. (2025). A Review of Current Trends and Advances in Analytical Methods for Determination of ACE Inhibitors Combinations with Hydrochlorothiazide. Journal of Drug Design and Medicinal Chemistry, 11(2), 13-30. https://doi.org/10.11648/j.jddmc.20251102.11

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Reid, I. O. A.; Osman, S. M.; Bakheet, S. M. A Review of Current Trends and Advances in Analytical Methods for Determination of ACE Inhibitors Combinations with Hydrochlorothiazide. J. Drug Des. Med. Chem. 2025, 11(2), 13-30. doi: 10.11648/j.jddmc.20251102.11

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AMA Style

Reid IOA, Osman SM, Bakheet SM. A Review of Current Trends and Advances in Analytical Methods for Determination of ACE Inhibitors Combinations with Hydrochlorothiazide. J Drug Des Med Chem. 2025;11(2):13-30. doi: 10.11648/j.jddmc.20251102.11

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@article{10.11648/j.jddmc.20251102.11,
  author = {Imad Osman Abu Reid and Sayda Mohamed Osman and Somia Mohammed Bakheet},
  title = {A Review of Current Trends and Advances in Analytical Methods for Determination of ACE Inhibitors Combinations with Hydrochlorothiazide
},
  journal = {Journal of Drug Design and Medicinal Chemistry},
  volume = {11},
  number = {2},
  pages = {13-30},
  doi = {10.11648/j.jddmc.20251102.11},
  url = {https://doi.org/10.11648/j.jddmc.20251102.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jddmc.20251102.11},
  abstract = {Background. Hypertension is a leading risk factor for cardiovascular diseases, contributing significantly to global morbidity and mortality. Combination therapy using an angiotensin-converting enzyme (ACE) inhibitor with a diuretic offers distinct advantages over monotherapy in managing hypertension. With the increasing use of fixed-dose combination therapies, there is a growing demand for analytical methods that can accurately, precisely, and cost-effectively assess these complex formulations. Objective. This review examines the various analytical methods used to analyze ACE inhibitor combinations with hydrochlorothiazide, focusing on studies published between 1990 and 2024. The methods are critically evaluated, compared, and assessed for their practical applicability. Results. A review of the literature revealed that different analytical techniques have been employed for the determination of ACE inhibitor–hydrochlorothiazide combinations. Recent trends indicate a preference for HPLC (48.7%), spectrophotometric methods (23.1%), thin-layer chromatography (TLC) (15.4%), capillary electrophoresis (7.7%), and Fourier transform infrared (FTIR) spectroscopy (5.1%). Conclusion and main ideas. HPLC remains the gold standard for the analysis of ACE inhibitor–hydrochlorothiazide combinations. However, alternative methods like spectrophotometry and TLC provide viable options for simpler and cost-effective analysis The selection of an appropriate analytical technique should align with analytical goals, regulatory compliance, and available resources. Future research may focus on advancing rapid and environmentally friendly analytical techniques.
},
 year = {2025}
}

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TY - JOUR
T1 - A Review of Current Trends and Advances in Analytical Methods for Determination of ACE Inhibitors Combinations with Hydrochlorothiazide

VL - 11
IS - 2
ER -

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