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Histopathologic Patterns of Endometrial Biopsies and Associated Factors in Hawassa University Comprehensive Specialized Hospital, Sidama Region, Ethiopia

Received: 5 December 2025     Accepted: 22 December 2025     Published: 16 January 2026
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Abstract

Background: The endometrium is a dynamic, hormonally sensitive and responsive tissue. The endometrium is a site of a broad array of pathological alterations. Both benign and malignant lesions and hormonal cyclic changes can occur in the endometrium. These lesions have a significant impact in the life of woman. Objective: The aim of current study was to determine histopathologic patterns of Endometrial Biopsies and the associatied factors in Hawassa University Comprehensive Specialized Hospital. Method: A five years retrospective cross-sectional study was conducted from reports of endometrial biopsies which were submitted to the pathology department of HUCSH from September 2019 G.C to August 2024 G.C. Result: A total of 204 endometrial biopsies were analysed in this study that fulfil the inclusion criteria. The youngest age was 20 years and oldest was 79 years with mean age of 44.1 years and standard deviation of 11.939. 187 (91.7%) samples was Manual vacuum aspirations and 17 (8.3%) was hysterectomy specimens. The commonest histopathologic finding was chronic endometritis 55 (27%), followed by endometrial polyp 38 (18.6%), secretory endometrium 30 (14.7%) and proliferative endometrium 23 (11.3%). The other important patterns include endometrial hyperplasia without atypia 18 (8.8%), Atypical endometrial hyperplasia 16 (7.8%), endometrial cancer 20 (9.8%) and Tuberculosis 4 (2%). From the endometrial cancer cases, the commonest is endometroid endometrial carcinoma 8 (9.8%), followed by serous endometrial carcinoma 4 (2%), MMMT 3 (1.5%), endometrial stromal sarcoma 3 (1.5%) and clear cell endometrial carcinoma 2 (1%). The histopathologic patterns was significantly associated with age groups (p=0.01) and parity (p=0.036). Conclusion: Chronic endometritis is the commonest histopathologic finding.

Published in Medicine and Health Sciences (Volume 2, Issue 1)
DOI 10.11648/j.mhs.20260201.15
Page(s) 40-48
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2026. Published by Science Publishing Group

Keywords

Histopathologic Patterns, Endometrial Biopsies, Hawassa Comprehensive Specialized Hospital

References
[1] JohnR, Goldblum, LauraW. Lamps, JesseK. Mckenney JM. Rosai and Ackerman’s Surgical Pathology 11th ed. Elsevier, 2017; 2018.
[2] Singh, G., Cue, L., & Puckett, Y. (2024). Endometrial hyperplasia. In StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. Updated April 30, 2024. Retrieved from
[3] Mahdy H, Vadakekut ES, Crotzer D. Endometrial Cancer. 2024 Apr 20. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025 Jan–.
[4] Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May; 71(3): 209-249.
[5] Kumar V, Abbas AK, Aster JC. Robbins & Cotran Pathologic Basis of Disease Ninth Edition 2021. 1408 p.
[6] TY - JOUR - Brahmaiah, Jyoti- Kuppareddy, Lalitha - Papireddygari, Vijay - Begum, CR -2022/10/01 - Histomorphological Spectrum of Endometrial Tissue in Abnormal Uterine Bleeding.
[7] S., A., G., P., & D., S. (2021). Study of histopathological patterns of endometrium in abnormal uterine bleeding. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 10(4), 1401–1405.
[8] Vijayaraghavan, A., Jadhav, C., Pradeep, B., Bindu, H., & Kumaran, S. (2022). A histopathological study of endometrial biopsy samples in abnormal uterine bleeding. Cureus.
[9] Abubakar M, Kabir B, Liman AA, Shehu SM, Kankia BL, Yahya A, et al. Histopathologic analysis of endometrial biopsies in a Northern Nigerian Teaching Hospital. Ann Trop Pathol 2020;
[10] Review of histopathologic findings of endometrial biopsy done at a tertiary referral hospital in urban Ethiopia Lemi B Tolu, Solomon Kabtamu, MustefaAbedella, GarummaToluFeyissa, Elias SenbetobioRxiv 2020.04.16.044610;
[11] Endometrial biopsies patterns among women attending Moi Teaching and Referral Hospital, Kenya, Andeso Grace PARIPEX Indian Journal of Research Volume 10, Issue 8, august 2021.
[12] Birmeka, M., & Bekele, D. (2024). Distribution of the pattern, incidence, and determinants of sexually transmitted infections among patients attending Adari Hospital, Hawassa City, Sidama Region, Ethiopia. Healthcare in Low-resource Settings, 12(4).
[13] Forae, G., & Aligbe, J. (2015). Histopathological Patterns of Endometrial Lesions in Patients with Abnormal Uterine Bleeding in a Cosmopolitan Population. Journal of Basic and Clinical Reproductive Sciences, 2(2), 101–104.
[14] Alshdaifat, E. H., AlHorani, S. S., Al-Sous, M. M., Al-Horani, A. S., Sahawneh, F. E., & Sindiani, A. M. (2022). Histopathological pattern of endometrial biopsies in patients with abnormal uterine bleeding in a tertiary referral hospital in Jordan. Annals of Saudi Medicine, 42(3), 204–213.
[15] Bohîlțea RE, Sajin M, Furtunescu F, Bohîlțea LC, Mihart A, Baros A, Anca AF. Clinical and pathological correlations in endometrial pathology. J Med Life. 2015 Oct-Dec; 8(4): 552-62.
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    Alembo, M. D., Engida, G. G., Mante, B. M., Asefa, E. A. (2026). Histopathologic Patterns of Endometrial Biopsies and Associated Factors in Hawassa University Comprehensive Specialized Hospital, Sidama Region, Ethiopia. Medicine and Health Sciences, 2(1), 40-48. https://doi.org/10.11648/j.mhs.20260201.15

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    ACS Style

    Alembo, M. D.; Engida, G. G.; Mante, B. M.; Asefa, E. A. Histopathologic Patterns of Endometrial Biopsies and Associated Factors in Hawassa University Comprehensive Specialized Hospital, Sidama Region, Ethiopia. Med. Health Sci. 2026, 2(1), 40-48. doi: 10.11648/j.mhs.20260201.15

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    AMA Style

    Alembo MD, Engida GG, Mante BM, Asefa EA. Histopathologic Patterns of Endometrial Biopsies and Associated Factors in Hawassa University Comprehensive Specialized Hospital, Sidama Region, Ethiopia. Med Health Sci. 2026;2(1):40-48. doi: 10.11648/j.mhs.20260201.15

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  • @article{10.11648/j.mhs.20260201.15,
      author = {Mishame Damtew Alembo and Ghion Getnet Engida and Bamlak Markos Mante and Eyosafet Abera Asefa},
      title = {Histopathologic Patterns of Endometrial Biopsies and Associated Factors in Hawassa University Comprehensive Specialized Hospital, Sidama Region, Ethiopia},
      journal = {Medicine and Health Sciences},
      volume = {2},
      number = {1},
      pages = {40-48},
      doi = {10.11648/j.mhs.20260201.15},
      url = {https://doi.org/10.11648/j.mhs.20260201.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.mhs.20260201.15},
      abstract = {Background: The endometrium is a dynamic, hormonally sensitive and responsive tissue. The endometrium is a site of a broad array of pathological alterations. Both benign and malignant lesions and hormonal cyclic changes can occur in the endometrium. These lesions have a significant impact in the life of woman. Objective: The aim of current study was to determine histopathologic patterns of Endometrial Biopsies and the associatied factors in Hawassa University Comprehensive Specialized Hospital. Method: A five years retrospective cross-sectional study was conducted from reports of endometrial biopsies which were submitted to the pathology department of HUCSH from September 2019 G.C to August 2024 G.C. Result: A total of 204 endometrial biopsies were analysed in this study that fulfil the inclusion criteria. The youngest age was 20 years and oldest was 79 years with mean age of 44.1 years and standard deviation of 11.939. 187 (91.7%) samples was Manual vacuum aspirations and 17 (8.3%) was hysterectomy specimens. The commonest histopathologic finding was chronic endometritis 55 (27%), followed by endometrial polyp 38 (18.6%), secretory endometrium 30 (14.7%) and proliferative endometrium 23 (11.3%). The other important patterns include endometrial hyperplasia without atypia 18 (8.8%), Atypical endometrial hyperplasia 16 (7.8%), endometrial cancer 20 (9.8%) and Tuberculosis 4 (2%). From the endometrial cancer cases, the commonest is endometroid endometrial carcinoma 8 (9.8%), followed by serous endometrial carcinoma 4 (2%), MMMT 3 (1.5%), endometrial stromal sarcoma 3 (1.5%) and clear cell endometrial carcinoma 2 (1%). The histopathologic patterns was significantly associated with age groups (p=0.01) and parity (p=0.036). Conclusion: Chronic endometritis is the commonest histopathologic finding.},
     year = {2026}
    }
    

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  • TY  - JOUR
    T1  - Histopathologic Patterns of Endometrial Biopsies and Associated Factors in Hawassa University Comprehensive Specialized Hospital, Sidama Region, Ethiopia
    AU  - Mishame Damtew Alembo
    AU  - Ghion Getnet Engida
    AU  - Bamlak Markos Mante
    AU  - Eyosafet Abera Asefa
    Y1  - 2026/01/16
    PY  - 2026
    N1  - https://doi.org/10.11648/j.mhs.20260201.15
    DO  - 10.11648/j.mhs.20260201.15
    T2  - Medicine and Health Sciences
    JF  - Medicine and Health Sciences
    JO  - Medicine and Health Sciences
    SP  - 40
    EP  - 48
    PB  - Science Publishing Group
    UR  - https://doi.org/10.11648/j.mhs.20260201.15
    AB  - Background: The endometrium is a dynamic, hormonally sensitive and responsive tissue. The endometrium is a site of a broad array of pathological alterations. Both benign and malignant lesions and hormonal cyclic changes can occur in the endometrium. These lesions have a significant impact in the life of woman. Objective: The aim of current study was to determine histopathologic patterns of Endometrial Biopsies and the associatied factors in Hawassa University Comprehensive Specialized Hospital. Method: A five years retrospective cross-sectional study was conducted from reports of endometrial biopsies which were submitted to the pathology department of HUCSH from September 2019 G.C to August 2024 G.C. Result: A total of 204 endometrial biopsies were analysed in this study that fulfil the inclusion criteria. The youngest age was 20 years and oldest was 79 years with mean age of 44.1 years and standard deviation of 11.939. 187 (91.7%) samples was Manual vacuum aspirations and 17 (8.3%) was hysterectomy specimens. The commonest histopathologic finding was chronic endometritis 55 (27%), followed by endometrial polyp 38 (18.6%), secretory endometrium 30 (14.7%) and proliferative endometrium 23 (11.3%). The other important patterns include endometrial hyperplasia without atypia 18 (8.8%), Atypical endometrial hyperplasia 16 (7.8%), endometrial cancer 20 (9.8%) and Tuberculosis 4 (2%). From the endometrial cancer cases, the commonest is endometroid endometrial carcinoma 8 (9.8%), followed by serous endometrial carcinoma 4 (2%), MMMT 3 (1.5%), endometrial stromal sarcoma 3 (1.5%) and clear cell endometrial carcinoma 2 (1%). The histopathologic patterns was significantly associated with age groups (p=0.01) and parity (p=0.036). Conclusion: Chronic endometritis is the commonest histopathologic finding.
    VL  - 2
    IS  - 1
    ER  - 

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Author Information
  • Department of Pathology, Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia

  • Department of Pathology, Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia

  • Department of Pharmacy, Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia

  • Hawassa Health Department, Tilte Health Centre, Hawassa, Ethiopia

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