Abstract: Background: During the last two decades, research about GATA-3, Ki-67, p53 expressions have been done, but it is still a debate on their use in predicting breast cancer patients’ prognosis and survival rate. Expressions of GATA-3 decreased with increasing of histopathology grading of breast cancer and increase with decrease of histopathology grading of breast cancer. The level expression of Ki-67 has a positive relation with breast cancer histopathology grading. p53 has no correlation with high grade differentiation of breast cancer. p53 is a transcription factor which is activated as a part of cellular stress response that can regulate genes’ cellular process, including apoptosis and senescence. Aim: To determine correlation between expressions of GATA 3, Ki-67 and p53 with histopathology grading of breast cancer in Makassar, Indonesia. Methods: Antibody monoclonal GATA 3, Ki-67 and p53 on the nucleus cell were detected with immunohistochemistry method. The positive and negative expressions of GATA 3, Ki-67 and p53 were assessed using scoring system according to the proportion of positive cell and coloring intensities. Results: There is no correlation between the higher positive expression ofp53 and higher expression of histopathology grading of breast cancer (P = 0.089). While Ki-67 had positive association with higher grade malignancy (P = 0.03). However, there was no association between GATA-3 expression and histopathology grading. Conclusion: In our research we found there is no correlation between higher expression of p53 and low expression of GATA-3 with higher histopathology grading of breast cancer. High expression of Ki-67 have significantly statistic analysis with high expression of histopathology grading of mammary cancer.Abstract: Background: During the last two decades, research about GATA-3, Ki-67, p53 expressions have been done, but it is still a debate on their use in predicting breast cancer patients’ prognosis and survival rate. Expressions of GATA-3 decreased with increasing of histopathology grading of breast cancer and increase with decrease of histopathology gradin...Show More
Abstract: Mucinous cystadenocarcinoma in men is very rare; we reported 1 case of mucinous cystadenocarcinoma in the pancreatic disease institute of Wuhan union hospital in China. The aim of the study was to focus our attention on the gender of this patient. The mucinous cystadenocarcinoma is a pathology frequently seen among women. The clinical presentation of this patient is a characteristic which deserves to be described.Abstract: Mucinous cystadenocarcinoma in men is very rare; we reported 1 case of mucinous cystadenocarcinoma in the pancreatic disease institute of Wuhan union hospital in China. The aim of the study was to focus our attention on the gender of this patient. The mucinous cystadenocarcinoma is a pathology frequently seen among women. The clinical presentation ...Show More
Abstract: The purpose of this study was to examine total white blood cell count (TWBCC), absolute neutrophil count (ANC), absolute lymphocyte count (ALC), and neutrophil-to-lymphocyte ratio’s (NLR) association with the risk of incident breast cancer (BCa). A prospective analysis was conducted among a cohort of 2,873 women from the First National Health and Nutrition Examination Survey (NHANES I) Epidemiologic Follow-up Study. In the present analysis, the association found between lower ALC and increased BCa risk was no longer statistically significant after adjusting for age. Additionally, no statically significant associations were found between any level of ANC, NLR, and TWBCC with incident BCa. Therefore, additional studies, which address the limitations encountered in the present analysis, are needed to validate, or rule out, their use as biomarkers of BCa risk in women.Abstract: The purpose of this study was to examine total white blood cell count (TWBCC), absolute neutrophil count (ANC), absolute lymphocyte count (ALC), and neutrophil-to-lymphocyte ratio’s (NLR) association with the risk of incident breast cancer (BCa). A prospective analysis was conducted among a cohort of 2,873 women from the First National Health and N...Show More